Antihyperalgesic activity of chlorogenic acid in experimental neuropathic pain

Bagdas D., ÇİNKILIÇ N., Ozboluk H. Y., ÖZYİĞİT M. Ö., GÜRÜN M. S.

JOURNAL OF NATURAL MEDICINES, cilt.67, sa.4, ss.698-704, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 67 Sayı: 4
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1007/s11418-012-0726-z
  • Dergi Adı: JOURNAL OF NATURAL MEDICINES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.698-704
  • Anahtar Kelimeler: Antihyperalgesic, Chlorogenic acid, Chronic constrictive nerve injury, Neuropathic pain, Rat, OXYGEN SPECIES ROS, INFLAMMATORY PAIN, RAT, POLYPHENOLS
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Chlorogenic acid (CGA) is a natural organic phenolic compound that is found in many plants, fruits and vegetables. CGA has beneficial bioactivities and strong therapeutic effects in inflammatory processes. CGA-rich fractions have analgesic activity but CGA has not been tested previously in neuropathic pain, which results from tissue damage, inflammation or injury of the nervous system. Chronic constrictive nerve injury (CCI) is a peripheral neuropathic pain model which initiates an inflammatory cascade. We aimed to determine possible antihyperalgesic effects of CGA in neuropathic pain. Our study showed for the first time that CGA [50, 100 and 200 mg/kg; intraperitoneally (i.p.)] produced significant dose- and time-dependent antihyperalgesic activity in CCI-induced neuropathic pain. In addition, chronic administration of CGA (100 mg/kg/day; i.p. for 14 days) prevented the development of mechanical hyperalgesia and attenuated CCI-induced histopathological changes. On the other hand, CGA (200 mg/kg) did not affect falling latencies of rats in the rota rod test. Hence, CGA might represent a novel potential therapeutic option for the management of neuropathic pain.