Safety and Effectiveness of a 2009 H1N1 Vaccine in Chronic Kidney Disease Children


DÖNMEZ O. , Akaci O., Albayrak N., Altas A.

NEPHRON CLINICAL PRACTICE, vol.128, no.3-4, pp.341-344, 2014 (Journal Indexed in SSCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 128 Issue: 3-4
  • Publication Date: 2014
  • Doi Number: 10.1159/000368410
  • Title of Journal : NEPHRON CLINICAL PRACTICE
  • Page Numbers: pp.341-344
  • Keywords: Child, Chronic kidney diseases, Dialysis, Influenza, Renal transplantation, INFLUENZA-A H1N1, PANDEMIC INFLUENZA, TRANSPLANT RECIPIENTS, HEMODIALYSIS-PATIENTS, IMMUNIZATION, EFFICACY

Abstract

Background/Aims: Influenza vaccination is the most effective method for preventing influenza infection and its complications. The risk groups are children with chronic kidney diseases (CKDs) such as children on peritoneal dialysis (PD) and hemodialysis (HD), predialysis CKD (pCKD) and renal transplant (RTx) patients and immunosuppressed children. The aim of the present study was to assess the safety and immunogenicity of a single administration of a monovalent inactivated pandemic (H1N1) 2009 vaccine in children with CKD. Methods: Patients were given a single intramuscular injection of 0.5 ml of monovalent inactivated vaccine. Results: Totally, there were 25 pediatric patients with a diagnosis of CKD (16 PD, 2 HD, 3 pCKD and 4 RTx). Seroconversion was observed in 15 of the 16 patients with PD. Seroconversion occurred in all patients undergoing pCKD and HD. However, 3 of the RTx patients were seronegative. Conclusion: This study demonstrated a high level of immunogenicity and safety of an (H1N1) 2009 influenza vaccine in children with CKD. (C) 2014 S. Karger AG, Basel