Immunohistochemical localization of insulin like growth factor-I receptors in the mice intestine

Zik B., Yagci A., Altunbas K.

INDIAN VETERINARY JOURNAL, vol.82, no.6, pp.652-655, 2005 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 82 Issue: 6
  • Publication Date: 2005
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.652-655
  • Bursa Uludag University Affiliated: Yes


Proliferation of the gastrointestinal mucosa is stimulated by the growth factors (IGF-I, TGF-alpha, EGF), as well as the gastrointestinal hormones, gastrin, neurotensin (NT), and peptide YY (PYY) (Hopfner et al., 2002). IGF-I and IGF-II receptors are present in normal rat intestinal epithelium (Young et. al., 1090) and in human colonic epithelium (Rouyer-Fessard et al., 1990), while. IGF-I receptors were seen in porcine small intestine (Schober et al., 1990). Termanini et al., (1990) showed the anatomic distribution of IGF-I receptors in all layers of rabbit gastrointestinal tract by autoradiography. The present study was planned to determine the distribution of IGF-I receptors in all layers of the adult mice intestinal tract using immunohistochemical method with suitable antibody.