Immunohistochemical localization of insulin like growth factor-I receptors in the mice intestine

Zik B., Yagci A., Altunbas K.

INDIAN VETERINARY JOURNAL, cilt.82, sa.6, ss.652-655, 2005 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 82 Sayı: 6
  • Basım Tarihi: 2005
  • Dergi Adı: INDIAN VETERINARY JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.652-655
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Proliferation of the gastrointestinal mucosa is stimulated by the growth factors (IGF-I, TGF-alpha, EGF), as well as the gastrointestinal hormones, gastrin, neurotensin (NT), and peptide YY (PYY) (Hopfner et al., 2002). IGF-I and IGF-II receptors are present in normal rat intestinal epithelium (Young et. al., 1090) and in human colonic epithelium (Rouyer-Fessard et al., 1990), while. IGF-I receptors were seen in porcine small intestine (Schober et al., 1990). Termanini et al., (1990) showed the anatomic distribution of IGF-I receptors in all layers of rabbit gastrointestinal tract by autoradiography. The present study was planned to determine the distribution of IGF-I receptors in all layers of the adult mice intestinal tract using immunohistochemical method with suitable antibody.