Immunohistochemical expression of human epidermal growth factor receptor (HER)-4 and prognosis in patients with metastatic breast cancer

DELİGÖNÜL, ADEM; EVRENSEL, TÜRKKAN; Avci, Nilufer; UĞRAŞ, NESRİN; Ture, Mehmet; ÇUBUKÇU, ERDEM; Hartavi, Mustafa; Olmez, Omer; Kurt, Ender; TOLUNAY, ŞAHSİNE; Kanat, Ozkan; Manavoglu, Osman

Immunohistochemical expression of human epidermal growth factor receptor (HER)-4 and prognosis in patients with metastatic breast cancer

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DELİGÖNÜL A., EVRENSEL T., Avci N., UĞRAŞ N., Ture M., ÇUBUKÇU E., ...More

JOURNAL OF BUON, vol.21, no.3, pp.564-569, 2016 (SCI-Expanded)

Publication Type: Article / Article
Volume: 21 Issue: 3
Publication Date: 2016
Journal Name: JOURNAL OF BUON
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.564-569
Bursa Uludag University Affiliated: Yes

Abstract

Purpose: The clinical value of HER4 - a cell surface receptor that belongs to the human epidermal growth factor receptor family - for predicting survival outcomes in patients with breast cancer remains controversial. Herein, we sought to investigate the prognostic significance of HER4 immunohistochemical expression with respect to progression-free survival (PFS) and overall survival (OS) in Turkish patients with metastatic breast cancer (MBC).