ADAMTS4, 5, 9, and 15 Expressions in the Autopsied Brain of Patients with Alzheimer's Disease: A Preliminary Immunohistochemistry Study

Pehlivan, Sultan; FEDAKAR, RECEP; Eren, Bulent; Akyol, Sumeyya; Eren, Filiz; TÜRKMEN İNANIR, NURSEL; Gurses, Murat; Ural, Mustafa; Tagil, Suleyman; Demircan, Kadir

doi:10.5455/bcp.20150706034008

ADAMTS4, 5, 9, and 15 Expressions in the Autopsied Brain of Patients with Alzheimer's Disease: A Preliminary Immunohistochemistry Study

Atıf İçin Kopyala

Pehlivan S., FEDAKAR R., Eren B., Akyol S., Eren F., TÜRKMEN İNANIR N., ...Daha Fazla

KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY, cilt.26, sa.1, ss.7-14, 2016 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 26 Sayı: 1
Basım Tarihi: 2016
Doi Numarası: 10.5455/bcp.20150706034008
Dergi Adı: KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.7-14
Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Objective: Recent studies performed in the central nervous system highlight the pathophysiological relevance of A disintegrin-like and metalloproteinase with thrombospondin motifs (ADAMTS) genes and their protein products. The determination of alterations in expression profiles of ADAMTS family genes in Alzheimer's disease (AD) patients may contribute to the explanation of tissue pathology and also new ideas for remedial approaches for this incurable but preventable disease. Therefore, the goal of this study was to describe and identify the distribution, characteristics, and any changes in the expression, in other words, immunoreactivity, for aggrecanases (ADAMTS4, 5, 9, and 15) proteins in AD brain.