OT-404, multi-targeted anti-cancer agent affecting tumor proliferation, chemo-resistance, and angiogenesis
CANCER LETTERS, vol.332, no.1, pp.55-62, 2013 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 332 Issue: 1
- Publication Date: 2013
- Doi Number: 10.1016/j.canlet.2013.01.016
- Journal Name: CANCER LETTERS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.55-62
- Bursa Uludag University Affiliated: Yes
Abstract
There is a need for a comprehensive anti-cancer strategy that simultaneously targets abnormal proliferation, angiogenesis rates, and development of chemotherapy resistance. We have identified a small molecule, OT-404, that effectively inhibited proliferation and angiogenesis of either chemo-sensitive or resistant human cancer cells and enhanced cancer cell sensitivity to different chemotherapy. In vivo studies of human tumor xenografts in nude mice showed that OT-404, used alone or encapsulated into nanoparticles, inhibited the growth of doxorubicin-resistant breast cancer MCF-7 by more than 80%, and by 95% when combined with doxorubicin. These findings provide evidence for the potential of OT-404 in cancer management. (c) 2013 Published by Elsevier Ireland Ltd.