Analysis of apoptotic, platelet-derived, endothelial-derived, and tissue factor-positive microparticles of children with acute lymphoblastic leukemia during induction therapy


Yenigurbuz F. D. , Kizmazoglu D., Ates H., Erdem M., Tufekci O., Yilmaz S., ...More

BLOOD COAGULATION & FIBRINOLYSIS, vol.30, no.4, pp.149-155, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 4
  • Publication Date: 2019
  • Doi Number: 10.1097/mbc.0000000000000811
  • Journal Name: BLOOD COAGULATION & FIBRINOLYSIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.149-155
  • Keywords: acute lymphoblastic leukemia, childhood, microparticles, thromboembolism, CIRCULATING MICROPARTICLES, THROMBOSIS, CANCER, PREVALENCE, ACTIVATION, DISEASE, EVENTS, CELLS
  • Bursa Uludag University Affiliated: No

Abstract

Objectives Thromboembolism is one of the most common complications during induction therapy of pediatric acute lymphoblastic leukemia (ALL). Procoagulant microparticles in the circulation may cause thromboembolic events. The aim of our study was to determine the levels of apoptotic, platelet-derived, endothelial-derived, and tissue factor-positive microparticles of children with ALL at diagnosis and during induction therapy.