Comparison of reference intervals derived by direct and indirect methods based on compatible datasets obtained in Turkey

Ozarda Y., Ichihara K., Jones G., Streichert T., Ahmadian R.

CLINICA CHIMICA ACTA, vol.520, pp.186-195, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 520
  • Publication Date: 2021
  • Doi Number: 10.1016/j.cca.2021.05.030
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.186-195
  • Bursa Uludag University Affiliated: Yes


Background: Indirect derivation of reference intervals (RIs) from the laboratory information system (LIS) has been recently pursued. We aimed at evaluating the accuracy of indirectly predicted RIs compared to the RIs established directly from healthy subjects in the nationwide RI study in Turkey, targeting 25 major chemistry analytes.