The Antinociceptive and Antiinflammatory Properties of 3-furan-2-yl-N-p-tolyl-acrylamide, a Positive Allosteric Modulator of alpha 7 Nicotinic Acetylcholine Receptors in Mice


Bagdas D., Targowska-Duda K. M. , Lopez J. J. , Perez E. G. , Arias H. R. , Damaj M. I.

ANESTHESIA AND ANALGESIA, vol.121, no.5, pp.1369-1377, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 121 Issue: 5
  • Publication Date: 2015
  • Doi Number: 10.1213/ane.0000000000000902
  • Title of Journal : ANESTHESIA AND ANALGESIA
  • Page Numbers: pp.1369-1377

Abstract

BACKGROUND: Positive allosteric modulators (PAMs) facilitate endogenous neurotransmission and/or enhance the efficacy of agonists without directly acting on the orthosteric binding sites. In this regard, selective 7 nicotinic acetylcholine receptor type II PAMs display antinociceptive activity in rodent chronic inflammatory and neuropathic pain models. This study investigates whether 3-furan-2-yl-N-p-tolyl-acrylamide (PAM-2), a new putative 7-selective type II PAM, attenuates experimental inflammatory and neuropathic pains in mice.