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Vatansever E. C., Kilic K., Ozer M. S., Koza G., Mengeş N., Balci M.
TETRAHEDRON LETTERS, vol.56, pp.5386-5389, 2015 (SCI-Expanded)
Article / Article
Science Citation Index Expanded (SCI-EXPANDED), Scopus
Alkynes, Cyclization, Alkynones, 2-Mercaptoacetaldehyde, 2,3-Disubstituted thiophenes, ONE-POT SYNTHESIS, FACILE SYNTHESIS, SUBSTITUTED THIOPHENES, HIGH-EFFICIENCY, ORGANIC-DYES, DERIVATIVES, LORNOXICAM, ANNULATION, POLYMERS, FURANS
Bursa Uludag University Affiliated:
A concise and regioselective approach for the synthesis of 2,3-disubstituted thiophene derivatives has been developed. The synthetic strategy relies on the reaction of an in situ generated 2-mercaptoacetaldehyde with various alkynones. Furthermore, we calculated the energy gap between the HOMO and the LUMO orbitals of all compounds and observed that the introduction of a strong electron-withdrawing group decreased the HOMO-LUMO energy gap. (C) 2015 Elsevier Ltd. All rights reserved.