Body fat distribution has no effect on serum visfatin levels in healthy female subjects

ERSOY C., Sadikoglu G., Orhan H., Guclu M., SARANDÖL E., Akgun M. D., ...Daha Fazla

CYTOKINE, cilt.49, sa.3, ss.275-278, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Sayı: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.cyto.2009.11.011
  • Dergi Adı: CYTOKINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.275-278
  • Anahtar Kelimeler: General obesity, Visceral obesity, Visfatin, TYPE-2 DIABETES-MELLITUS, COLONY-ENHANCING FACTOR, INSULIN-RESISTANCE, VISCERAL FAT, METABOLIC SYNDROME, PLASMA, CHOLESTEROL, OVERWEIGHT, GLUCOSE, PROTEIN
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Obesity is the presence of either abnormal absolute amount or relative proportion of body fat. Contrary to gluteal obesity, visceral obesity is associated with different metabolic alterations including insulin resistance (IR). A relatively new adipocytokine visfatin is shown to be expressed predominantly in visceral fat and exhibit insulin-mimicking effects in rodents. It is still unclear whether serum visfatin levels are associated with increased total or visceral fat mass in humans. The aim of our study was to investigate the relation between visfatin and obesity parameters namely body mass index (BMI) and waist circumference (WaC) and IR in healthy female subjects. Eighty one female subjects >= 20 years of age, having no diagnosis of glucose intolerance or diabetes, hypertension and dyslipidemia were chosen. The patients were divided into four groups according to their BMI and WaC values. Serum visfatin and HOMA-IR levels did not differ among groups. No correlation was detected between serum visfatin levels and obesity and metabolic parameters. In conclusion, we demonstrated that body fat distribution did not affect serum visfatin levels in healthy female subjects. Further studies are needed to clarify the exact factors influencing and determining serum visfatin levels and its clinical reflections. (C) 2009 Elsevier Ltd. All rights reserved.