Effect of Benzene on liver functions in rats (Rattus norvegicus)

DERE E., ARI F.

ENVIRONMENTAL MONITORING AND ASSESSMENT, cilt.154, ss.23-27, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 154
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1007/s10661-008-0374-7
  • Dergi Adı: ENVIRONMENTAL MONITORING AND ASSESSMENT
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.23-27
  • Anahtar Kelimeler: Benzene, Lactate dehydrogenase, Alkaline phosphatase, Alanine amino transferase, Aspartate amino transferase, MICROSOMAL MEMBRANE, HL-60 CELLS, EXPOSURE, TISSUES, PHOSPHOROTHIONATE, METABOLITES, BLOOD, ACID
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Rats (Rattus norvegicus) were intraperitoneally injected with a 100 mg kg (-aEuro parts per thousand 1) dosage of benzene, a toxic and carcinogenic agent widely used for industrial purposes. Changes in lactate dehydrogenase (LDH), alkaline phosphatase (ALP), alanine amino transferase (ALT), aspartate amino transferase (AST) activities in serum of rats were investigated at 2, 4, 8, 16, 32, and 64 h following injection. Serum physiological was administered to control group. Activities were measured using autoanalyzer. Benzene caused significant activations in LDH, ALP, and AST activities in the serum at some test hours (p < 0.05). When compared with the control groups, although an increase occurred in ALT activity, it was seem that this increase wasn't significant (p > 0.05).