The purpose of the study was to evaluate erythrocyte indices and platelet indices in dogs with leishmaniasis (CL, L. infantum). CL was diagnosed by polymerase chain reaction, and confirmed by western blott in 54 dogs. These dogs were divided into three groups; asymptomatic (n=16), oligosymptomatic (n=16), and symptomatic (n=22). Leishmaniasis free 25 dogs were served as controls. Microcytic or normocytic-hypochromic anemia was observed in dogs with CL. There was not a significant difference on RDW (RBC distribution width) groups. PLT count was slightly lower in dogs with CL in all clinical stages (p<0.05), compared to controls. MPV (mean platelet volume) in dogs with CL was higher (P<0.05) compared with controls, and it was significantly higher in asymptomatic dogs. RBC (red blood cell) and platelet indices may be useful parameters during course of the leismaniasis. These indices may have diagnostic properties but are not enough to differentiate of the clinical stages of CL. Further comprehensive studies are needed to clinical use of RBC and platelets indices in canine practice.