Akademik Veri Yönetim Sistemi
Turkish Journal of Dermatopathology, cilt.6, ss.103-107, 1997 (Scopus)
Viruses coagulopathy and autoimmunity are the most favourite theories in the aetiopathogenesis of Behcet's disease. Recently, being marked to mechanisms of cellular immunity; some changes in Langerhans cells whose primary functions are to present antigenic stimuli to T-cells, have been reported. In this study, 3 different samples of skin lesions of 6 patients with active Behcet's disease were investigated electron microscopically. Erythema nodosum and superficial thrombophlebitis of 2 distinct patients, papulopustular pathergy lesions of 3 patients and normal skin of 1 patient were biopsied. Normal skin samples of other patients and 2 healthy individuals were also taken. Langerhans cells were morphologically same in patients and in normal individuals. Birbeck granules were not found in occasional cells and there were some cells called indetermined form. Langerhans cells of patients were determined as sited in superficial layers of epidermis, especially in pathergy lesions.