Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis

Yilmaz, Yusuf; Dolar, MAHMUT; Ulukaya, Engin; Akgoz, Semra; Keskin, Murat; Kiyici, Murat; Aker, Sibel; Yilmaztepe, ARZU; Gurel, SELİM; Gulten, Macit; Nak, Selim

doi:10.3748/wjg.v13.i6.837

Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis

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Yilmaz Y., Dolar E., Ulukaya E., Akgoz S., Keskin M., Kiyici M., ...More

WORLD JOURNAL OF GASTROENTEROLOGY, vol.13, no.6, pp.837-844, 2007 (SCI-Expanded)

Publication Type: Article / Article
Volume: 13 Issue: 6
Publication Date: 2007
Doi Number: 10.3748/wjg.v13.i6.837
Journal Name: WORLD JOURNAL OF GASTROENTEROLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.837-844
Keywords: steatosis, steatohepatitis, cytokeratin 18, M30-antigen, M65-antigen, FATTY LIVER-DISEASE, NATURAL-HISTORY, CELL-DEATH, HEPATOCYTE APOPTOSIS, VARIABILITY, FEATURES, BIOPSY, SERA
Bursa Uludag University Affiliated: Yes

Abstract

AIM: To investigate whether serum levels of two soluble forms of extracellular cytokeratin 18 (M30-antigen and M65-antigen) may differentiate nonalcoholic steatohepatitis (NASH) from simple steatosis in patients with nonalcoholic fatty liver disease (NAFLD).