The high potential of methyl laurate as a recyclable competitor to conventional toxic solvents in [3 + 2] cycloaddition reactions

Yıldırım A., Göker M.

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, vol.21, pp.2389-2415, 2025 (SCI-Expanded)

  • Publication Type: Article / Article
  • Volume: 21
  • Publication Date: 2025
  • Doi Number: 10.3762/bjoc.21.184
  • Journal Name: BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
  • Journal Indexes: Scopus, Science Citation Index Expanded (SCI-EXPANDED), Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, Chemical Abstracts Core, Directory of Open Access Journals
  • Page Numbers: pp.2389-2415
  • Bursa Uludag University Affiliated: Yes

Abstract

In the present study, 21 fused isoxazolidines were synthesized in yields ranging from good to excellent. Methyl laurate was identified as the easily accessible optimal solvent medium for the reaction, and the related compounds were obtained through straightforward isolation techniques in a relatively short time frame (5–80 minutes). A comprehensive investigation was conducted utilizing various web platforms, encompassing ecological and environmental risk assessments, toxicity, pesticide similarity, and biodegradability of methyl laurate in comparison with a series of conventional organic solvents, water, some fatty acids and their derivatives. The findings of this investigation revealed that methyl laurate exhibited better green solvent properties when evaluated against other solvents.