Pregnancy under treatment of imatinib and successful labor in a patient with chronic myelogenous leukemia (CML) - Outcome of discontinuation of imatinib therapy after achieving a molecular remission

Ali R., Ozkalemkas F., Ozcelik T., Ozkocaman V., Ozan U., Kimya Y., ...Daha Fazla

LEUKEMIA RESEARCH, cilt.29, sa.8, ss.971-973, 2005 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 8
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.leukres.2005.01.009
  • Dergi Adı: LEUKEMIA RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.971-973
  • Anahtar Kelimeler: chronic myelogenous leukemia, pregnancy, imatinib, MANAGEMENT
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Because of the teratogenicity data in rats, it is recommended that women treated with imatinib should be aware of the potential teratogenicity of imatimb and effective contraception should be used during imatinib therapy to prevent pregnancy. We describe successful pregnancy and delivery, without any congenital anomaly, in a patient with CML under treatment of imatinib. The fetus had been exposed to imatinib for 8 weeks. The patient remained off treatment during gestation and cytogenetic relapse of CML (5 months after discontinuation of imatinib therapy) developed at seventh month of gestation. (c) 2005 Elsevier Ltd. All rights reserved.