Study for the Diagnostic Screening of Paroxysmal Nocturnal Hemoglobinuria in Older Patients with Unexplained Anemia and/or Cytopenia

Ozdemir, Zehra; İLHAN, OSMAN; Ozet, Gulsum; Falay, Mesude; Yenerel, Mustafa; Tuglular, Tulin; Turgut, Mehmet; GÜVENÇ, BİROL; ÜNAL, ALİ; Ayyildiz, Orhan; ANDIÇ, NESLİHAN; Hacihanefioglu, Abdullah; ŞAHİN, FAHRİ; ŞENCAN, MEHMET; ALİ, RIDVAN; ÖZSAN, GÜNER; YILDIRIM, Rahşan; TİFTİK, EYÜP; TOMBAK, ANIL; SALİM, OZAN; KAYA, EMİN; Akay, Olga; Okan, Vahap; PEHLİVAN, MUSTAFA; SAYDAM, GÜRAY

doi:10.7754/clin.lab.2020.191218

Study for the Diagnostic Screening of Paroxysmal Nocturnal Hemoglobinuria in Older Patients with Unexplained Anemia and/or Cytopenia

Ozdemir Z. N., İLHAN O., Ozet G., Falay M., Yenerel M., Tuglular T., ...More

CLINICAL LABORATORY, vol.66, no.9, pp.1709-1715, 2020 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 66 Issue: 9
Publication Date: 2020
Doi Number: 10.7754/clin.lab.2020.191218
Journal Name: CLINICAL LABORATORY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
Page Numbers: pp.1709-1715
Bursa Uludag University Affiliated: Yes

Abstract

Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired hematopoietic stem cell disease that may lead to weakness and death of patients, if unrecognized and untreated. Although consensus guidelines were reviewed recently for the diagnostic screening of PNH with multi-parameter flow cytometry (FCM), until now, no study has investigated the efficiency of such clinical indications in older patients.