Inhibition of mast cell tryptase attenuates neuroinflammation via PAR-2/p38/NF kappa B pathway following asphyxial cardiac arrest in rats

Ocak U., Ocak P., Huang L., Xu W., Zuo Y., Li P., ...Daha Fazla

JOURNAL OF NEUROINFLAMMATION, cilt.17, sa.1, 2020 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1186/s12974-020-01808-2
  • Dergi Adı: JOURNAL OF NEUROINFLAMMATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Anahtar Kelimeler: Asphyxia, Cardiac arrest, Cognitive, Global brain ischemia, Mast cell, Neuroinflammation, PAR-2, Tryptase, PROTEASE-ACTIVATED RECEPTORS, GLOBAL CEREBRAL-ISCHEMIA, INTRACEREBRAL HEMORRHAGE, MICROGLIA ACTIVATION, COLLAGEN-SYNTHESIS, BRAIN, SURVIVAL, PATHOPHYSIOLOGY, RESUSCITATION, INFILTRATION
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Background: Cardiac arrest survivors suffer from neurological dysfunction including cognitive impairment. Cerebral mast cells, the key regulators of neuroinflammation contribute to neuroinflammation-associated cognitive dysfunction. Mast cell tryptase was demonstrated to have a proinflammatory effect on microglia via the activation of microglial protease-activated receptor-2 (PAR-2). This study investigated the potential anti-neuroinflammatory effect of mast cell tryptase inhibition and the underlying mechanism of PAR-2/p-p38/NF kappa B signaling following asphyxia-induced cardiac arrest in rats.