Evaluation of insulin resistance and plasma levels for visfatin and resistin in obese and non-obese patients with polycystic ovary syndrome

ÖZ GÜL Ö., Cander S., Gul B., Acikgoz E., SARANDÖL E., ERSOY C.

EUROPEAN CYTOKINE NETWORK, vol.26, no.4, pp.73-78, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.1684/ecn.2015.0370
  • Journal Name: EUROPEAN CYTOKINE NETWORK
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.73-78
  • Keywords: polycystic ovary syndrome, insulin resistance, visfatin, resistin, obesity, BETA-CELL FUNCTION, METABOLIC SYNDROME, ADIPOSE-TISSUE, SERUM VISFATIN, RISK-FACTORS, WOMEN, SENSITIVITY, GLUCOSE, WEIGHT, ADIPONECTIN
  • Bursa Uludag University Affiliated: Yes

Abstract

This study was designed to evaluate insulin resistance and plasma levels of visfatin and resistin in obese and non-obese patients with polycystic ovary syndrome (PCOS). A total of 37 premenopausal PCOS patients with (n = 18, mean (SD) age: 27.5 (5.7 years) or without obesity (n = 19, mean (SD) age: 23.7 (3.1) years) and healthy volunteers (n = 18, mean (SD) age: 29.8 (4.1) years) were included in this study. Data on clinical characteristics, glycemic parameters and lipid parameters were recorded for each subject as were plasma visfatin and resistin levels. Mean (SD) HOMA-IR values were significantly higher in obese PCOS patients (3.4 (1.7)) compared with non-obese PCOS patients (2.0 (1.2), p<0.01) and controls (1.6 (0.8), p<0.01). No significant difference was noted between study groups in terms of plasma resistin (ng/mL) or visfatin (ng/mL) levels. There was no correlation between serum plasma visfatin (r = 0.127, p = 0.407) and resistin (r = -0.096, p = 0.544) levels and HOMA-IR. In conclusion, our findings revealed increased likelihood of metabolic and dyslipidemic manifestations in obese compared to non-obese PCOS patients, while no significant difference was noted in visfatin and resistin levels among PCOS patients in terms of co-morbid obesity and in comparison to controls.