Contemporary treatment approaches for metastatic colorectal cancer driven by BRAF V600 mutations

Kanat O., Ertas H., Caner B.

World Journal of Gastrointestinal Oncology, vol.12, no.10, pp.1080-1090, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 10
  • Publication Date: 2020
  • Doi Number: 10.4251/wjgo.v12.i10.1080
  • Journal Name: World Journal of Gastrointestinal Oncology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
  • Page Numbers: pp.1080-1090
  • Keywords: BRAF mutation, Metastatic colorectal cancer, Targeted, therapies, V600 mutations
  • Bursa Uludag University Affiliated: Yes


©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.The treatment of metastatic colorectal cancer (mCRC) harboring BRAF V600 mutations is challenging. These tumors are often refractory to standard treatment. Therefore, the patients may exhibit rapid clinical deterioration, depriving them of the chance to receive salvage therapy. In newly diagnosed patients with good performance status, the administration of an intensive chemotherapy regimen like FOLFOXIRI (5-fluorouracil, leucovorin, oxaliplatin, and irinotecan) along with the antiangiogenic agent bevacizumab can modify this aggressive behavior of the disease and improve patient clinical outcomes. The recently published results of the BEACON (Binimetinib, Encorafenib, and Cetuximab Combined to Treat BRAF-Mutant Colorectal Cancer) study demonstrated that a combination therapy consisting of BRAF, epidermal growth factor receptor, and mitogen-activated protein kinase kinase inhibitors could be a useful second-or third-line alternative. This review summarizes the current treatment strategies for BRAF-mutant mCRC.