Effects of hypertonic sodium chloride, hypertonic sodium chloride + sodium bicarbonate and hypertonic sodium chloride + ringer's lactade solution in the treatment of dogs with experimentally induced endotoxaemia


Turkish Journal of Veterinary and Animal Sciences, vol.27, no.2, pp.339-347, 2003 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 2
  • Publication Date: 2003
  • Journal Name: Turkish Journal of Veterinary and Animal Sciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.339-347
  • Keywords: sodium chloride, lactate ringer, sodium bicarbonate, endotoxaemia, dog, FLUID RESUSCITATION, SALINE SOLUTION, SHOCK, THERAPY, NEUTROPENIA, INHIBITION, INFUSION
  • Bursa Uludag University Affiliated: Yes


The aim of this study was to compare the effects of isotonic sodium chloride (ISS-0.9%), hypertonic sodium chloride (HSS-7.2%), HSS + lactate ringer solution (LRS) and HSS + sodium bicarbonate solution (SBS-1.3%) in the treatment of dogs with endotoxaemia. Endotoxaemia was induced by slow injection of a 1 mg/kg/i.v. dose of E. coli endotoxin (0111:B4). At the treatment stage, four groups, each composed of six dogs, were formed and a different treatment plan was carried out in each group: ISS, HSS, HSS + LRS and HSS + SBS. Clinical, haematological and biochemical examinations were performed before and after endotoxaemia. Hypotension (MAP < 60 mm Hg), leukopaenia and trombocytopaenia were observed during endotoxaemia in all dogs. MAP and plasma volume were increased in all groups except the ISS group. HCO-3 values were increased in the HSS + SBS group and decreased in the other groups. Therefore, it was concluded that the HSS + SBS combination was the most effective model of fluid therapy in the treatment of dogs with endotoxaemia.