Effects of long-term antidepressant treatment on oxidative status in major depressive disorder: A 24-week follow-up study

Kotan V. O., SARANDÖL E., Kirhan E., ÖZKAYA G., KIRLI S.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, vol.35, no.5, pp.1284-1290, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 5
  • Publication Date: 2011
  • Doi Number: 10.1016/j.pnpbp.2011.03.021
  • Journal Name: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1284-1290
  • Keywords: Antioxidants, Major depressive disorder, Malondialdehyde, Oxidative stress, CORONARY-ARTERY-DISEASE, LOW-DENSITY-LIPOPROTEIN, SUPEROXIDE-DISMUTASE, LIPID-PEROXIDATION, ANTIOXIDANT STATUS, NITRIC-OXIDE, OXIDIZED LDL, RAT-BRAIN, STRESS, PLASMA
  • Bursa Uludag University Affiliated: Yes

Abstract

Purpose: Major depressive disorder (MDD) is a devastating disease that afflicts large populations and has also been accepted to be an independent risk factor for cardiovascular disease (CVD). Oxidative stress seems to play an essential role in the relationship of MOD and CVD. We aimed to determine the level of oxidative stress in patients with MOD and to investigate the effects of long-term antidepressant (AD) treatment on the oxidative-antioxidative system parameters and CVD risk factors.