Epigallocatechin-3-gallate reduces the proliferation of benign prostatic hyperplasia cells via regulation of focal adhesions

ERBAYKENT TEPEDELEN B., Soya E., KORKMAZ M.

LIFE SCIENCES, cilt.191, ss.74-81, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 191
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.lfs.2017.10.016
  • Dergi Adı: LIFE SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.74-81
  • Anahtar Kelimeler: EGCG, BPH, Cytoskeleton, F-Actin, FAK, Paxillin, GREEN-TEA, EPITHELIAL-CELLS, METABOLIC SYNDROME, GROWTH-FACTOR, CANCER RISK, EXPRESSION, MIGRATION, KINASE, INHIBITION, APOPTOSIS
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Aims: Benign prostatic hyperplasia (BPH) is the most common urological disease that is characterized by the excessive growth of prostatic epithelial and stromal cells. Pharmacological therapy for BPH has limited use due to the many side effects so there is a need for new agents including natural compounds such as epigallocatechin-3-gallate (EGCG). This study was undertaken to assess the role of EGCG, suppressing the formation of BPH by reducing inflammation and oxidative stress, in cytoskeleton organization and ECM interactions via focal adhesions.