Discontinuation of RAAS Inhibition in Children with Advanced CKD

van den Belt, Sophie; Heerspink, Hiddo; Kirchner, Marietta; Gracchi, Valentina; Thurn-Valsassina, Daniela; KARABAY BAYAZIT, AYSUN; Niemirska, Anna; Canpolat, Nur; KAPLAN BULUT, İPEK; Azukaitis, Karolis; DÜZOVA, ALİ; Bacchetta, Justine; Shroff, Rukshana; Paripovic, Dusan; ÖZÇAKAR, ZEYNEP; Fidan, Kibriya; ERDOĞAN, HAKAN; Gellermann, Jutta; Wuehl, Elke; de Zeeuw, Dick; Melk, Anette; Querfeld, Uwe; Schaefer, Franz

doi:10.2215/cjn.09750819

Discontinuation of RAAS Inhibition in Children with Advanced CKD

van den Belt S. M., Heerspink H. J. L., Kirchner M., Gracchi V., Thurn-Valsassina D., KARABAY BAYAZIT A., ...More

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol.15, no.5, pp.625-632, 2020 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 15 Issue: 5
Publication Date: 2020
Doi Number: 10.2215/cjn.09750819
Journal Name: CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE
Page Numbers: pp.625-632
Bursa Uludag University Affiliated: Yes

Abstract

Background and objectives Although renin-angiotensin-aldosterone system inhibition (RAASi) is a cornerstone in the treatment of children with CKD, it is sometimes discontinued when kidney function declines. We studied the reasons of RAASi discontinuation and associations between RAASi discontinuation and important risk markers of CKD progression and on eGFR decline in the Cardiovascular Comorbidity in Children with CKD study.