Serum concentrations of human angiopoietin-like protein 3 in patients with nonalcoholic fatty liver disease: association with insulin resistance.


Yimaz Y., Ulukaya E., ATUĞ Ö., Dolar E.

European journal of gastroenterology & hepatology, vol.21, no.11, pp.1247-51, 2009 (SCI-Expanded) identifier identifier identifier

Abstract

Objective Insulin resistance is considered a key feature of nonalcoholic fatty liver disease (NAFLD). In this setting, experimental studies have suggested a potential role of angiopoietin-like (ANGPTL) proteins in the pathogenesis of hepatic steatosis and the metabolic syndrome. In this study, we sought to investigate the plasma levels of ANGPTL protein 3 (ANGPTL3) - a liver-derived protein that modulates plasma triglyceride clearance - in patients with definite nonalcoholic steatohepatitis (NASH, n = 40), borderline NASH (n = 8), simple fatty liver (n = 9), and healthy controls without evidence of liver disease (n = 14).