Aim Systemic sclerosis (SSc) is a chronic fibrotic collagen tissue disease. Leptin's role in regulating immune and inflammatory response has become increasingly evident. Resistin has pro-inflammatory properties and also is associated with inflammatory markers in some rheumatologic diseases. The purpose of this study was to determine serum leptin, resistin and tumor necrosis factor alpha (TNF-a) in SSc patients and evaluate their association with other frequently used laboratory and clinic findings. Method Sixteen patients were compared with 30 healthy women of similar age and body mass index. Serum leptin, resistin and TNF-a levels were measured by enzyme-linked immunosorbent assay and results were assessed by MannWhitney U -test and Spearman's correlation test. Results Leptin levels were significantly increased in the SSc group compared to controls (7789.43 +/- 1180.72 pg/mL, 1790.55 +/- 333.68 pg/mL, P < 0.0001). TNF-a was significantly elevated in patients and it was also positively correlated with leptin (25.30 +/- 2.16 pg/mL, 20.95 +/- 0.30 pg/mL, P = 0.001), (P = 0.002, r = 0.523). There was no association between leptin, resistin, TNF-a levels and skin score, activity score and disease duration in the SSc patients (P > 0.05). Conclusion Leptin, resistin and TNF-a levels were found to be higher in SSc in contrast to the control group. These adipokines may have differentiating roles in the pathogenesis of SSc. In order to verify these findings, further clinical studies are needed with larger patient groups.