Targeted delivery of cisplatin to tumor xenografts via the nanoparticle component of nano-diamino-tetrac

Sudha T., Bharali D. J., Yalcin M., Darwish N. H. E., Coskun M. D., Keating K. A., ...Daha Fazla

NANOMEDICINE, cilt.12, sa.3, ss.195-205, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.2217/nnm-2016-0315
  • Dergi Adı: NANOMEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.195-205
  • Anahtar Kelimeler: cisplatin, integrin, nanotetrac, NDAT, tetraiodothyroacetic acid, urinary bladder carcinoma, ACTIVATED PROTEIN-KINASE, TETRAIODOTHYROACETIC ACID, THYROID-HORMONE, CANCER-CELLS, PLATINUM, INTEGRIN, RECEPTOR, GROWTH, DRUGS
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Aim: Nano-diamino-tetrac (NDAT) targets a receptor on integrin alpha v beta 3; alpha v beta 3 is generously expressed by cancer cells and dividing endothelial cells and to a small extent by nonmalignant cells. The tetrac (tetraiodothyroacetic acid) of NDAT is covalently bound to a poly(lactic-co-glycolic acid) nanoparticle that encapsulates anticancer drugs. We report NDAT delivery efficiency of cisplatin to agent-susceptible urinary bladder cancer xenografts. Materials & methods: Cisplatin-loaded NDAT (NDAT-cisplatin) was administered to xenograft-bearing nude mice. Tumor size response and drug content were measured. Results: Intratumoral drug concentration was up to fivefold higher (p < 0.001) in NDAT-cisplatin-exposed lesions than with conventional systemic administration. Tumor volume reduction achieved was NDAT-cisplatin > NDAT without cisplatin > cisplatin alone. Conclusion: NDAT markedly enhances cisplatin delivery to urinary bladder cancer xenografts and increases drug efficacy.