Investigation of the Relationship Between Fok1 and Col1A1 Gene Polymorphisms and Development of Treatment-Related Bone Complications in Children with Acute Lymphoblastic Leukemia


Erdem M., Tufekci O., Kizildag S., Yilmaz S., Kizmazoglu D., Filibeli B. E. , ...More

TURKISH JOURNAL OF HEMATOLOGY, vol.36, no.1, pp.12-18, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.4274/tjh.galenos.2018.2018.0221
  • Journal Name: TURKISH JOURNAL OF HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.12-18
  • Keywords: Acute lymphoblastic leukemia, Bone mineral density, Genetic polymorphism, Osteonecrosis, Osteoporosis, RAY ABSORPTIOMETRY INTERPRETATION, SP1 BINDING-SITE, VITAMIN-D, MINERAL DENSITY, AVASCULAR NECROSIS, OSTEONECROSIS, CHILDHOOD, ADOLESCENTS, CALCIUM, RISK
  • Bursa Uludag University Affiliated: No

Abstract

Objective: In acute lymphoblastic leukemia (ALL), various clinical risk factors and genetic predispositions contribute to the development of bone complications during and after chemotherapy. In this study, we aimed to investigate whether vitamin D receptor (VDR) Fok1 and collagen protein Col1A1 Sp1-binding site gene polymorphisms, which are important in bone mineral and matrix formation, have effects on the development of bone abnormalities in childhood ALL survivors.