TURKISH JOURNAL OF HEMATOLOGY, vol.36, no.1, pp.12-18, 2019 (Journal Indexed in SCI)
Article / Article
Title of Journal :
TURKISH JOURNAL OF HEMATOLOGY
Acute lymphoblastic leukemia, Bone mineral density, Genetic polymorphism, Osteonecrosis, Osteoporosis, RAY ABSORPTIOMETRY INTERPRETATION, SP1 BINDING-SITE, VITAMIN-D, MINERAL DENSITY, AVASCULAR NECROSIS, OSTEONECROSIS, CHILDHOOD, ADOLESCENTS, CALCIUM, RISK
Objective: In acute lymphoblastic leukemia (ALL), various clinical risk factors and genetic predispositions contribute to the development of bone complications during and after chemotherapy. In this study, we aimed to investigate whether vitamin D receptor (VDR) Fok1 and collagen protein Col1A1 Sp1-binding site gene polymorphisms, which are important in bone mineral and matrix formation, have effects on the development of bone abnormalities in childhood ALL survivors.