Eco-friendly H2O2 oxidation of 1,2-dihydroquinazoline-3-oxides to quinazoline-3-oxides


Samandram R., ÇETİN KORUKÇU M. , COŞKUN N.

SYNTHETIC COMMUNICATIONS, 2021 (SCI İndekslerine Giren Dergi) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası:
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1080/00397911.2021.1934876
  • Dergi Adı: SYNTHETIC COMMUNICATIONS

Özet

2-Aminobenzaldehyde, 1-(2-aminophenyl)ethanone, and 2-aminophenyl phenyl methanone oximes 1 were reacted with aromatic aldehydes to give the corresponding 1,2-dihydroquinazoline-3-oxides 2. The latter were converted in high yields to a series of quinazoline-3-oxides 3 using an environmentally benign H2O2-tungstate oxidant system at room temperature. A high yielding one-pot procedure was also developed for the synthesis of compounds 3.