Effects of intranigral vs intrastriatal fetal mesencephalic neural grafts on motor behavior disorders in a rat Parkinson model.

Goren B., Kahveci N., Eyigor Ö., Alkan T., Korfali E., Ozluk K.

Surgical neurology, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume:
  • Publication Date: 2005
  • Doi Number: 10.1016/j.surneu.2005.07.038
  • Journal Name: Surgical neurology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: drug-induced rotational behavior, fetal ventral mesencephalic grafts, intrastriatal grafts, neural transplantation, 6-hydroxydopamine, RECOVERY FOLLOWING TRANSPLANTATION, EMBRYONIC VENTRAL MESENCEPHALON, NIGROSTRIATAL DOPAMINE PATHWAY, BILATERAL 6-OHDA LESIONS, CELL-SUSPENSION GRAFTS, SUBSTANTIA-NIGRA, ADULT-RAT, NEURITE GROWTH, RE-INNERVATION, NEONATAL RATS
  • Bursa Uludag University Affiliated: Yes

Abstract

Background: Numerous experimental and clinical studies have shown that intrastriatal fetal mesencephalic grafts grow, survive, and reinnervate host brain tissue, resulting in partial recovery of motor deficits. In addition, pharmacological evidence indicates that these grafts increase dopamine secretion in lesioned brain. However, to date, no grafting method has completely restored the nigrostriatal pathway, and there is no consensus on optimal graft numbers or locations. This study compared outcomes with multiple striatal grafts vs a single intranigral graft in a rat model of Parkinson disease.