Genotoxic biomonitoring study of population residing in pesticide contaminated regions in Goksu Delta: Micronucleus, chromosomal aberrations and sister chromatid exchanges

Ergene S., Celik A., Cavas T., Kaya F.

ENVIRONMENT INTERNATIONAL, cilt.33, sa.7, ss.877-885, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 7
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.envint.2007.04.003
  • Dergi Adı: ENVIRONMENT INTERNATIONAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.877-885
  • Anahtar Kelimeler: genotoxicty, micronucleus, pesticide exposure, smoking, sister chromatid, PERIPHERAL-BLOOD LYMPHOCYTES, BUCCAL EPITHELIAL-CELLS, OCCUPATIONAL-EXPOSURE, HERBICIDES ALACHLOR, CYTOGENETIC DAMAGE, CANCER-RISK, ASSAY, FREQUENCY, WORKING, TOOL
  • Bursa Uludağ Üniversitesi Adresli: Hayır

Özet

Pesticides are widely used throughout. the world in agriculture to protect crops and in public health to control diseases. Nevertheless, exposure to pesticides represents a potential risk to humans. This paper describes a study of possible genetic damage in the people living in regions contaminated with complex mixture of pesticides in Goksu Delta. In this study, used methods were chromosomal aberration (CA), sister chromatid exchange analysis (SCE) in the peripheral blood lymphocytes, and micromucleus (NIN) assay in the buccal epithelial cells. In the present investigation, 32 affected subjects consist of 16 smoking and 16 non-smokings and an equal number of control subjects were assessed for genome damage. Micronucleus (MN), Broken egg (BE), Karyorrhexis (KR), Karyolysis (KL) and Binucleus (BN) frequencies were higher in affected subjects than in controls. Smoking had a statistically significant effect on the Micronucleus, Karyorrhexis and Binucleus frequencies for both the control and the exposed group. Also smoking and exposure affected the frequency of sister chromatid exchange and chromosomal aberrations compared with control groups. (c) 2007 Elsevier Ltd. All rights reserved.