Vanadyl sulfate, taurine, and combined vanadyl sulfate and taurine treatments in diabetic rats: Effects on the oxidative and antioxidative systems


Tas S. , Sarandol E. , Ayvalik S. , Serdar Z., Dirican M.

ARCHIVES OF MEDICAL RESEARCH, vol.38, no.3, pp.276-283, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 3
  • Publication Date: 2007
  • Doi Number: 10.1016/j.arcmed.2006.09.018
  • Title of Journal : ARCHIVES OF MEDICAL RESEARCH
  • Page Numbers: pp.276-283
  • Keywords: streptozotocin, nicotinamide, oxidative stress, paraoxonase, vanadyl sulfate, taurine, ERYTHROCYTE LIPID-PEROXIDATION, HUMAN-SERUM PARAOXONASE, VASCULAR COMPLICATIONS, INSULIN SENSITIVITY, FATTY RAT, IN-VITRO, MELLITUS, STREPTOZOTOCIN, STRESS, METABOLISM

Abstract

Background. Vanadyl sulfate (VS) and taurine are two promising agents in the treatment of diabetes related to their anti hyperglycemic, antihyperlipidemic, and hyperinsulinemic effects. Data about the effects of VS on the oxidant-antioxidant system is limited and controversial. However, taurine is a well-documented antioxidant agent and our aim was to investigate the effects of VS, taurine and VS and taurine combination on the oxidative-antioxidative systems in streptozotocin-nicotinamide (STZ-NA) diabetic rats.