The prevalence of 4G/5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene in central serous chorioretinopathy and its association with plasma PAI-1 levels

Sari E., Yazici A., Eser B., Erol M. K., Kilic A., Ermis S. S., ...Daha Fazla

CUTANEOUS AND OCULAR TOXICOLOGY, cilt.33, sa.4, ss.270-274, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 4
  • Basım Tarihi: 2014
  • Doi Numarası: 10.3109/15569527.2013.854372
  • Dergi Adı: CUTANEOUS AND OCULAR TOXICOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.270-274
  • Anahtar Kelimeler: 4G/5G polymorphism of PAI-1 gene, central serous chorioretinopathy, serum PAI-1 level, PROMOTER, ABNORMALITIES, RISK
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Context: Central serous chorioretinopathy (CSCR) is a poorly understood disease and the choroidal circulation abnormality induced by the plasminogen activator inhibitor type 1 (PAI-1) seems to be associated with the pathogenesis. There are many reports indicating that 4G/5G polymorphism of the PAI-1 gene is a risk factor for several diseases related to the elevated serum levels of PAI-1.