The prevalence of 4G/5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene in central serous chorioretinopathy and its association with plasma PAI-1 levels


Sari E., Yazici A., Eser B., Erol M. K. , Kilic A., Ermis S. S. , ...More

CUTANEOUS AND OCULAR TOXICOLOGY, vol.33, no.4, pp.270-274, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 4
  • Publication Date: 2014
  • Doi Number: 10.3109/15569527.2013.854372
  • Journal Name: CUTANEOUS AND OCULAR TOXICOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.270-274
  • Keywords: 4G/5G polymorphism of PAI-1 gene, central serous chorioretinopathy, serum PAI-1 level, PROMOTER, ABNORMALITIES, RISK
  • Bursa Uludag University Affiliated: Yes

Abstract

Context: Central serous chorioretinopathy (CSCR) is a poorly understood disease and the choroidal circulation abnormality induced by the plasminogen activator inhibitor type 1 (PAI-1) seems to be associated with the pathogenesis. There are many reports indicating that 4G/5G polymorphism of the PAI-1 gene is a risk factor for several diseases related to the elevated serum levels of PAI-1.