Serum free and phospholipid-bound choline decrease after surgery and methylprednisolone administration in dogs

Ilcol Y., Yilmaz Z., Ulus I.

Neuroscience Letters, vol.339, no.3, pp.195-198, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 339 Issue: 3
  • Publication Date: 2003
  • Doi Number: 10.1016/s0304-3940(03)00035-1
  • Journal Name: Neuroscience Letters
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.195-198
  • Keywords: free choline, phospholipid-bound choline, stress, glucocorticoid, dog, methylprednisolone, cortisol, ACETYLCHOLINE, STRESS
  • Bursa Uludag University Affiliated: Yes


We designed this study to determine whether serum free and phospholipid-bound choline concentrations change after surgery or methylprednisolone treatment in dogs and rats. In dogs, serum free and phospholipid-bound choline concentrations were decreased by 29% and 17% immediately after abdominal-pelvic surgery under xylasine+ketamine anesthesia, respectively, and both remained low for 24 h. Serum cortisol was elevated after surgery. The elevation in serum cortisol was inversely correlated with the decreases in free (r=-0.737; P<0.001) and phospholipid-bound (r=-0.771; P<0.001) choline concentrations. After methyprednisolone administration (5-20 mg/kg) free and phospholipid-bound choline concentrations decreased in a dose- and time-dependent manner. In rats, either surgery or methylprednisolone failed to alter serum free choline concentrations while phospholipid-bound choline decreased after surgery. These data show that the decrease in serum choline after surgery results from the increase in circulating glucocorticoids. © 2003 Elsevier Science Ireland Ltd. All rights reserved.