Canine prostatic cancer cell line (LuMa) with osteoblastic bone metastasis

Elshafae S. M. , Dirksen W. P. , Alasonyalilar-Demirer A. , Breitbach J., Yuan S., Kantake N., ...More

PROSTATE, vol.80, no.9, pp.698-714, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 80 Issue: 9
  • Publication Date: 2020
  • Doi Number: 10.1002/pros.23983
  • Title of Journal : PROSTATE
  • Page Numbers: pp.698-714


Background Osteoblastic bone metastasis represents the most common complication in men with prostate cancer (PCa). During progression and bone metastasis, PCa cells acquire properties similar to bone cells in a phenomenon called osteomimicry, which promotes their ability to metastasize, proliferate, and survive in the bone microenvironment. The mechanism of osteomimicry resulting in osteoblastic bone metastasis is unclear.