Canine prostatic cancer cell line (LuMa) with osteoblastic bone metastasis

Elshafae S. M., Dirksen W. P., Alasonyalilar-Demirer A., Breitbach J., Yuan S., Kantake N., ...More

PROSTATE, vol.80, no.9, pp.698-714, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 80 Issue: 9
  • Publication Date: 2020
  • Doi Number: 10.1002/pros.23983
  • Journal Name: PROSTATE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, Gender Studies Database, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.698-714
  • Bursa Uludag University Affiliated: Yes


Background Osteoblastic bone metastasis represents the most common complication in men with prostate cancer (PCa). During progression and bone metastasis, PCa cells acquire properties similar to bone cells in a phenomenon called osteomimicry, which promotes their ability to metastasize, proliferate, and survive in the bone microenvironment. The mechanism of osteomimicry resulting in osteoblastic bone metastasis is unclear.