Canine prostatic cancer cell line (LuMa) with osteoblastic bone metastasis

Elshafae S. M. , Dirksen W. P. , Alasonyalilar-Demirer A. , Breitbach J., Yuan S., Kantake N., ...More

PROSTATE, vol.80, no.9, pp.698-714, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 80 Issue: 9
  • Publication Date: 2020
  • Doi Number: 10.1002/pros.23983
  • Title of Journal : PROSTATE
  • Page Numbers: pp.698-714

Abstract

Background Osteoblastic bone metastasis represents the most common complication in men with prostate cancer (PCa). During progression and bone metastasis, PCa cells acquire properties similar to bone cells in a phenomenon called osteomimicry, which promotes their ability to metastasize, proliferate, and survive in the bone microenvironment. The mechanism of osteomimicry resulting in osteoblastic bone metastasis is unclear.