Cup-like Blasts in 2 Pediatric Patients With NPM-1-Positive Acute Myeloid Leukemia
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, vol.40, no.4, 2018 (SCI-Expanded, Scopus)
- Publication Type: Article / Editorial Material
- Volume: 40 Issue: 4
- Publication Date: 2018
- Doi Number: 10.1097/mph.0000000000001110
- Journal Name: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Bursa Uludag University Affiliated: No
Abstract
Cup-like phenotype is defined in some subtypes of acute myeloid leukemia (AML) and have been associated with NPM-1 and/or FLT3-ITD positivity in the presence of normal karyotype in >60% of patients. Herein we present two pediatric AML-M1 patients with cuplike nuclear morphology and NPM-1 positivity. Both patients were negative for FLT3-ITD mutation. NPM-1 mutation and FLT3-ITD mutation should be kept in mind in AML patients with cup-like blast morphology as these two mutations are important molecular markers for prognosis, risk group classification and also for response to treatment.