Cup-like Blasts in 2 Pediatric Patients With NPM-1-Positive Acute Myeloid Leukemia


Tufekci O., Erdem M., Oren H., Yilmaz S.

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, vol.40, no.4, 2018 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Editorial Material
  • Volume: 40 Issue: 4
  • Publication Date: 2018
  • Doi Number: 10.1097/mph.0000000000001110
  • Journal Name: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus

Abstract

Cup-like phenotype is defined in some subtypes of acute myeloid leukemia (AML) and have been associated with NPM-1 and/or FLT3-ITD positivity in the presence of normal karyotype in >60% of patients. Herein we present two pediatric AML-M1 patients with cuplike nuclear morphology and NPM-1 positivity. Both patients were negative for FLT3-ITD mutation. NPM-1 mutation and FLT3-ITD mutation should be kept in mind in AML patients with cup-like blast morphology as these two mutations are important molecular markers for prognosis, risk group classification and also for response to treatment.