Overexpression of Mfsd2a attenuates blood brain barrier dysfunction via Cav-1/Keap-1/Nrf-2/HO-1 pathway in a rat model of surgical brain injury


Ocak P., Ocak U., Sherchan P., Gamdzyk M., Tang J., Zhang J. H.

EXPERIMENTAL NEUROLOGY, vol.326, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 326
  • Publication Date: 2020
  • Doi Number: 10.1016/j.expneurol.2020.113203
  • Journal Name: EXPERIMENTAL NEUROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: Blood brain barrier, Brain edema, Cav-1, Caveolae, Mfsd2a, Surgical brain injury, EXPRESSION, INHIBITION, STRESS, NRF2
  • Bursa Uludag University Affiliated: No

Abstract

Introduction: Disruption of the blood brain barrier (BBB) and subsequent cerebral edema formation is one of the major adverse effects of brain surgery, leading to postoperative neurological dysfunction. Recently, Mfsd2a has been shown to have a crucial role for the maintenance of BBB functions. In this study, we aimed to evaluate the role of Mfsd2a on BBB disruption following surgical brain injury (SBI) in rats.