Overexpression of Mfsd2a attenuates blood brain barrier dysfunction via Cav-1/Keap-1/Nrf-2/HO-1 pathway in a rat model of surgical brain injury

Ocak P., Ocak U., Sherchan P., Gamdzyk M., Tang J., Zhang J. H.

EXPERIMENTAL NEUROLOGY, cilt.326, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 326
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.expneurol.2020.113203
  • Dergi Adı: EXPERIMENTAL NEUROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Blood brain barrier, Brain edema, Cav-1, Caveolae, Mfsd2a, Surgical brain injury, EXPRESSION, INHIBITION, STRESS, NRF2
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Introduction: Disruption of the blood brain barrier (BBB) and subsequent cerebral edema formation is one of the major adverse effects of brain surgery, leading to postoperative neurological dysfunction. Recently, Mfsd2a has been shown to have a crucial role for the maintenance of BBB functions. In this study, we aimed to evaluate the role of Mfsd2a on BBB disruption following surgical brain injury (SBI) in rats.