Proteomic Analysis of Liver Preservation Solutions Prior to Liver Transplantation

COSKUN A., BAYKAL A. T., Oztug M., KAZAN D., KAYA E., EMİROĞLU R., ...Daha Fazla

CURRENT PROTEOMICS, cilt.16, sa.2, ss.119-135, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 2
  • Basım Tarihi: 2019
  • Doi Numarası: 10.2174/1570164615666180905104543
  • Dergi Adı: CURRENT PROTEOMICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.119-135
  • Anahtar Kelimeler: Liver, mass spectrometry, organ preservation solution, proteomics, liver transplantation, hypothermia, ISCHEMIA-REPERFUSION INJURY, GLUTATHIONE-S-TRANSFERASE, GRAFT FUNCTION, COLD ISCHEMIA, UW SOLUTION, EXPRESSION, ARGINASE, ENZYME, ALPHA, CELLS
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Objective: Transplantation is the preferred treatment for patients with end-stage liver diseases. However, in clinical practice, functional preservation of the liver is a major concern before the transplantation. Although various protective solutions are used (in combination with hypothermia), the functional preservation time for liver is still limited to hours. We analyzed the preservation medium to detect the proteins released from the liver during storage period.