The variation in the beta-casein genotypes and its effect on milk yield and genomic values in Holstein-Friesian cows

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Ardicli S., Aldevir O., Aksu E., Gumen A.

Animal Biotechnology, cilt.35, ss.1-10, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1080/10495398.2023.2267614
  • Dergi Adı: Animal Biotechnology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Compendex, EMBASE, Environment Index, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.1-10
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

The A2 milk marker is gaining popularity worldwide; thus, many farms plan to convert their

dairy cattle herds to the A2A2 genotype. Variation in beta-casein genotypes needs to be

monitored in large dairy cattle populations. Therefore we aimed to evaluate the genotypic

distributions, population genetics, and diversity parameters in Holstein-Friesian cows. A total

of 1200 cattle were genotyped using the AffymetrixVR AxiomVR array system. We performed

an association analysis regarding the CSN2 genotypes and phenotypic traits, including lactation

and test-day milk yield. We next evaluated the effects of the genotypes considering the

genetic merit of the animals. Animals were grouped based on their PTAs for milk production,

fat, protein, and daughter pregnancy rate. Thus, we tested the genotype x genetic

merit interaction for significance. The A2 allele frequency is remarkably high (0.68), and the

heterozygous genotype is predominant (46.25%). The marker showed intermediate variability

and diversity levels, indicating a considerable frequency of the A1A1 genotype (9.33%)

remains in the population. ANOVA results showed no significant association between the

CSN2 genotypes and milk yield traits. A similar finding is valid for the genotype x genetic

merit regarding the genomic test results. The data presented here may be helpful for further

investigations and applications on A2 milk production.