Oxidative Stress and Intracranial Hypertension after Aneurysmal Subarachnoid Hemorrhage

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Hao G., OCAK P., Mo J.

ANTIOXIDANTS, vol.11, no.12, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 11 Issue: 12
  • Publication Date: 2022
  • Doi Number: 10.3390/antiox11122423
  • Journal Name: ANTIOXIDANTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, Food Science & Technology Abstracts, Directory of Open Access Journals
  • Bursa Uludag University Affiliated: Yes


Intracranial hypertension is a common phenomenon in patients with aneurysmal subarachnoid hemorrhage (aSAH). Elevated intracranial pressure (ICP) plays an important role in early brain injuries and is associated with unfavorable outcomes. Despite advances in the management of aSAH, there is no consensus about the mechanisms involved in ICP increases after aSAH. Recently, a growing body of evidence suggests that oxidative stress (OS) may play a crucial role in physio-pathological changes following aSAH, which may also contribute to increased ICP. Herein, we discuss a potential relation between increased ICP and OS, and resultantly propose antioxidant mechanisms as a potential therapeutic strategy for the treatment of ICP elevation following aSAH.