Effects of tibolone and transdermal estrogen on lipid levels and apolipoprotein B-containing lipoprotein oxidation in postmenopausal women Postmenopozal kadinlarda tibolon ve transdermal ostrojen kullaniminin lipid duzeylerine ve apolipoprotein B-iceren lipoproteinlerin oksidasyonuna etkisi


DİRİCAN M. , SARANDÖL E. , UNCU G. , Tokullugil H.

Jinekoloji ve Obstetrik Dergisi, vol.13, no.4, pp.202-207, 1999 (Refereed Journals of Other Institutions) identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 4
  • Publication Date: 1999
  • Title of Journal : Jinekoloji ve Obstetrik Dergisi
  • Page Numbers: pp.202-207
  • Keywords: Antioxidants, Lipoprotein oxidation, Tibolone, Transdermal estrogen

Abstract

OBJECTIVE: The objective of this study was to compare the effects on serum lipid levels and oxidation of non-high density lipoprotein (HDL) fraction of tibolone with that of transdermal estrogen. STUDY DESIGN: The study included thirty women in total (fifteen in each treatment group) between 44 and 58 years of age. Serum concentrations of lipids and apolipoproteins, lipoprotein (a), total carotene, vitamin E and various water-soluble antioxidants were measured. We analyzed the susceptibility of non-HDL fraction to copper-mediated oxidation. RESULTS: Tibolone users had lower triglyceride (TG), HDL-cholesterol (HDL-C) and very low density lipoprotein-cholesterol and higher carotene/TG, vitamin E/TG and vitamin E/total cholesterol+TG levels. The amount of malondialdehyde (measured as thiobarbituric acid-reactive substances) generated during oxidation was significantly lower in the tibolone-receiving group at the 120th, 150th and 180th minutes of incubation. CONCLUSION: Our study indicates that tibolone protects apolipoprotein B-containing lipoproteins in postmenopausal women from oxidation that is related to its effects on serum lipid concentrations.