Interferon-alpha treatment of molluscum contagiosum in a patient with hyperimmunoglobulin E syndrome.

Kilic S. Ş., Kilicbay F.

Pediatrics, vol.117, no.6, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 117 Issue: 6
  • Publication Date: 2006
  • Doi Number: 10.1542/peds.2005-2706
  • Journal Name: Pediatrics
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: hyperimmunoglobulin E syndrome, Job's syndrome, molluscum contagiosum, interferon-alpha, HYPER-IGE SYNDROME, IMIQUIMOD
  • Bursa Uludag University Affiliated: Yes


We report widely disseminated molluscum contagiosum that occurred in a 9-year-old boy secondary to hyperimmunoglobulin E syndrome, a primary immunodeficiency disorder. Cutaneous examination revealed numerous, widespread, skin-colored to translucent, firm, umbilicated papules of varying sizes. They were distributed throughout the perineal and gluteal areas and bilaterally over his lower limbs. A biopsy specimen from his skin lesion demonstrated lobulated epidermal growth that consisted of keratinocytes with large intracytoplasmic eosinophilic inclusion bodies and a central crater. These findings were consistent with the diagnosis of molluscum contagiosum. Many treatments for his skin lesions were ineffective, including physical destruction or manual extrusion of the lesions; cryotherapy; curettage; and topical therapies with phenol, trichloroacetic acid, and imiquimod. The patient was treated successfully with subcutaneous interferon-alpha for 6 months without any adverse effect.