New water-soluble copper (II) complexes including 4,7-dimethyl-1,10-phenanthroline and L-tyrosine: Synthesis, characterization, DNA interactions and cytotoxicities

Inci D., Aydın R., Yılmaz D., Mutlu Gençkal H., Vatan Ö., Çinkılıç N., ...More

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, vol.136, pp.761-770, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 136
  • Publication Date: 2015
  • Doi Number: 10.1016/j.saa.2014.09.093
  • Journal Name: SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.761-770
  • Keywords: Copper(II), 4,7-Dimethyl-1,10-phenanthroline, L-tyrosine, Single crystal X-ray diffraction, DNA binding and cleavage, Cytotoxicity, MIXED-LIGAND COMPLEXES, CRYSTAL-STRUCTURE, WEAK-INTERACTIONS, RUTHENIUM(II) COMPLEXES, BINDING PROPERTIES, CLEAVAGE, PHOTOCLEAVAGE, 1,10-PHENANTHROLINE, FLUORESCENCE, STABILITIES
  • Bursa Uludag University Affiliated: Yes

Abstract

Two new water-soluble copper(II) complexes, [Cu(dmphen)(2)(NO3)]NO3 (1), [Cu(dmphen)(tyr)(H2O)] NO3 center dot H2O (2) and the diquartemary salt of dmphen (dmphen = 4,7-dimethyl-1,10-phenanthroline and tyr = L-tyrosine), have been synthesized and characterized by elemental analysis, H-1 NMR, C-13 NMR and IR spectroscopy, thermal analysis and single crystal X-ray diffraction techniques. The CT-DNA binding properties of these compounds have been investigated by absorption, emission spectroscopy and thermal denaturation measurements. The supercoiled pBR322 plasmid DNA cleavage activity of these compounds has been explored by agarose gel electrophoresis. The cytotoxicity of these compounds against MCF-7, Caco-2, A549 cancer cells and BEAS-2B healthy cells was also studied by the XTT method. Complexes 1 and 2 exhibit significant cytotoxicity, with lower IC50 values than those of cisplatin. (C) 2014 Elsevier B.V. All rights reserved.