Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) as a Marker of Diabetic Nephropathy in Type 1 Diabetic Patients

Sisman P., ÖZ GÜL Ö., Dirican M., Bal A. S., CANDER S., ERTÜRK E.

CLINICAL LABORATORY, vol.66, no.1-2, pp.9-16, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 66 Issue: 1-2
  • Publication Date: 2020
  • Doi Number: 10.7754/clin.lab.2019.190326
  • Journal Name: CLINICAL LABORATORY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.9-16
  • Keywords: neutrophil gelatinase-associated lipocalin (NGAL), type 1 diabetes, diabetic nephropathy, KIDNEY INJURY MOLECULE-1, TUBULAR MARKERS, BIOMARKERS, DISEASE, PATHOPHYSIOLOGY, PROTEINURIA, PROGRESSION, DIAGNOSIS, DAMAGE
  • Bursa Uludag University Affiliated: Yes

Abstract

Background: Glomerular and tubulointerstitial damage plays a role in renal function failure in diabetic patients. While both serum and urine levels of neutrophil gelatinase-associated lipocalin (NGAL) show significantly increased levels in acute renal pathologies, the NGAL increase in active phase indicates a reversible condition in chronic cases.