Microsatellite instability status affects gene expression profiles in early onset colorectal cancer patients.

Ak S., Tunca B., Yilmazlar T., Tezcan G., Çeçener G., Egeli Ü., ...Daha Fazla

The Journal of surgical research, cilt.185, sa.2, ss.626-37, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 185 Sayı: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.jss.2013.07.014
  • Dergi Adı: The Journal of surgical research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.626-37
  • Anahtar Kelimeler: Colorectal cancer, MSI, MSS, CK20, MAP3K8, REG1A, Early onset, MESSENGER-RNA EXPRESSION, REG-IV, CYTOKERATIN-20, CARCINOMAS, OVEREXPRESSION, IDENTIFICATION, CHEMOTHERAPY, ALPHA, DNA, DIFFERENTIATION
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Background: The association between microsatellite instability (MSI) status and gene expression profiles in the early onset sporadic colorectal cancer (CRC) has not been clearly established. The aim of this study was to identify the altered gene expression patterns depending on the MSI status of early onset CRC and determine specific biomarkers that could provide novel therapeutic molecular targets in the Turkish population.