Microsatellite instability status affects gene expression profiles in early onset colorectal cancer patients.


Ak S., Tunca B., Yilmazlar T., Tezcan G., Çeçener G., Egeli Ü., ...More

The Journal of surgical research, vol.185, no.2, pp.626-37, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 185 Issue: 2
  • Publication Date: 2013
  • Doi Number: 10.1016/j.jss.2013.07.014
  • Journal Name: The Journal of surgical research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.626-37
  • Keywords: Colorectal cancer, MSI, MSS, CK20, MAP3K8, REG1A, Early onset, MESSENGER-RNA EXPRESSION, REG-IV, CYTOKERATIN-20, CARCINOMAS, OVEREXPRESSION, IDENTIFICATION, CHEMOTHERAPY, ALPHA, DNA, DIFFERENTIATION
  • Bursa Uludag University Affiliated: Yes

Abstract

Background: The association between microsatellite instability (MSI) status and gene expression profiles in the early onset sporadic colorectal cancer (CRC) has not been clearly established. The aim of this study was to identify the altered gene expression patterns depending on the MSI status of early onset CRC and determine specific biomarkers that could provide novel therapeutic molecular targets in the Turkish population.