RESTORATION OF BLOOD-PRESSURE BY CHOLINE TREATMENT IN RATS MADE HYPOTENSIVE BY HEMORRHAGE
BRITISH JOURNAL OF PHARMACOLOGY, vol.116, no.2, pp.1911-1917, 1995 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 116 Issue: 2
- Publication Date: 1995
- Doi Number: 10.1111/j.1476-5381.1995.tb16682.x
- Journal Name: BRITISH JOURNAL OF PHARMACOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.1911-1917
- Bursa Uludag University Affiliated: No
Abstract
1 Intracerebroventricular (i.c.v.) injection of choline (25 - 150 mu g) increased blood pressure in rats made acutely hypotensive by haemorrhage. Intraperitoneal administration of choline (60 mg kg(-1)) also increased blood pressure, but to a lesser extent. Following i.c.v. injection of 25 mu g or 50 mu g of choline, heart rate did not change, while 100 mu g or 150 pg i.c.v. choline produced a slight and short lasting bradycardia. Choline (150 mu g) failed to alter the circulating residual volume of blood in haemorrhaged rats.