Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies


Ma C. S. , Wong N., Rao G., Avery D. T. , Torpy J., Hambridge T., ...More

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol.136, no.4, pp.993-1007, 2015 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 136 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.1016/j.jaci.2015.05.036
  • Journal Name: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.993-1007
  • Keywords: Follicular helper T cells, humoral immunity, primary immunodeficiencies, cytokine signaling, TRANSCRIPTION FACTOR STAT3, ANTIBODY-RESPONSES, HUMORAL IMMUNITY, IL-21 RECEPTOR, IFN-GAMMA, B-CELLS, DEFICIENCY, PHENOTYPE, AGAMMAGLOBULINEMIA, COMMITMENT

Abstract

Background: Follicular helper T (T-FH) cells underpin T cell-dependent humoral immunity and the success of most vaccines. T-FH cells also contribute to human immune disorders, such as autoimmunity, immunodeficiency, and malignancy. Understanding the molecular requirements for the generation and function of T-FH cells will provide strategies for targeting these cells to modulate their behavior in the setting of these immunologic abnormalities.