Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies

Ma, Cindy; Wong, Natalie; Rao, Geetha; Avery, Danielle; Torpy, James; Hambridge, Thomas; Bustamante, Jacinta; Okada, Satoshi; Stoddard, Jennifer; Deenick, Elissa; Pelham, Simon; Payne, Kathryn; Boisson-Dupuis, Stephanie; Puel, Anne; Kobayashi, Masao; Arkwright, Peter; Kilic, SARA; El Baghdadi, Jamila; Nonoyama, Shigeaki; Minegishi, Yoshiyuki; Mahdaviani, Seyed; Mansouri, Davood; Bousfiha, Aziz; Blincoe, Annaliesse; French, Martyn; Hsu, Peter; Campbell, Dianne; Stormon, Michael; Wong, Melanie; Adelstein, Stephen; Smart, Joanne; Fulcher, David; Cook, Matthew; Phan, Tri; Stepensky, Polina; Boztug, Kaan; Kansu, Aydan; Ikinciogullari, Aydan; Baumann, Ulrich; Beier, Rita; Roscioli, Tony; Ziegler, John; Gray, Paul; Picard, Capucine; Grimbacher, Bodo; Warnatz, Klaus; Holland, Steven; Casanova, Jean-Laurent; Uzel, Gulbu; Tangye, Stuart

doi:10.1016/j.jaci.2015.05.036

Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies

Atıf İçin Kopyala

Ma C. S., Wong N., Rao G., Avery D. T., Torpy J., Hambridge T., ...Daha Fazla

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, cilt.136, sa.4, ss.993-1007, 2015 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 136 Sayı: 4
Basım Tarihi: 2015
Doi Numarası: 10.1016/j.jaci.2015.05.036
Dergi Adı: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.993-1007
Anahtar Kelimeler: Follicular helper T cells, humoral immunity, primary immunodeficiencies, cytokine signaling, TRANSCRIPTION FACTOR STAT3, ANTIBODY-RESPONSES, HUMORAL IMMUNITY, IL-21 RECEPTOR, IFN-GAMMA, B-CELLS, DEFICIENCY, PHENOTYPE, AGAMMAGLOBULINEMIA, COMMITMENT
Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Background: Follicular helper T (T-FH) cells underpin T cell-dependent humoral immunity and the success of most vaccines. T-FH cells also contribute to human immune disorders, such as autoimmunity, immunodeficiency, and malignancy. Understanding the molecular requirements for the generation and function of T-FH cells will provide strategies for targeting these cells to modulate their behavior in the setting of these immunologic abnormalities.