JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol.136, no.4, pp.993-1007, 2015 (Peer-Reviewed Journal)
Article / Article
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Science Citation Index Expanded, Scopus
Follicular helper T cells, humoral immunity, primary immunodeficiencies, cytokine signaling, TRANSCRIPTION FACTOR STAT3, ANTIBODY-RESPONSES, HUMORAL IMMUNITY, IL-21 RECEPTOR, IFN-GAMMA, B-CELLS, DEFICIENCY, PHENOTYPE, AGAMMAGLOBULINEMIA, COMMITMENT
Background: Follicular helper T (T-FH) cells underpin T cell-dependent humoral immunity and the success of most vaccines. T-FH cells also contribute to human immune disorders, such as autoimmunity, immunodeficiency, and malignancy. Understanding the molecular requirements for the generation and function of T-FH cells will provide strategies for targeting these cells to modulate their behavior in the setting of these immunologic abnormalities.