Neuroprotective effects of melatonin administered alone or in combination with topiramate in neonatal hypoxic-ischemic rat model

ÖZYENER F., Cetinkaya M., ALKAN T., GÖREN B., KAFA İ. M., Kurt M. A., ...Daha Fazla

RESTORATIVE NEUROLOGY AND NEUROSCIENCE, cilt.30, sa.5, ss.435-444, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 5
  • Basım Tarihi: 2012
  • Doi Numarası: 10.3233/rnn-2012-120217
  • Dergi Adı: RESTORATIVE NEUROLOGY AND NEUROSCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.435-444
  • Anahtar Kelimeler: Combination therapy, hypoxia-ischemia, melatonin, neuroprotection, topiramate, BRAIN-DAMAGE, PROTECTIVE ROLE, CELL-DEATH, NEWBORN, INJURY, REDUCTION, INFANT
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Purpose: The objective of this study was to compare the effects of two neuroprotective agents; melatonin, a free radical scavenger and topiramate, AMPA/kainate receptor antagonist, administered alone or in combination in neonatal hypoxic-ischemic model.