Neuroprotective effects of melatonin administered alone or in combination with topiramate in neonatal hypoxic-ischemic rat model


ÖZYENER F. , Cetinkaya M., ALKAN T. , GÖREN B. , KAFA İ. M. , Kurt M. A. , ...More

RESTORATIVE NEUROLOGY AND NEUROSCIENCE, vol.30, no.5, pp.435-444, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 5
  • Publication Date: 2012
  • Doi Number: 10.3233/rnn-2012-120217
  • Title of Journal : RESTORATIVE NEUROLOGY AND NEUROSCIENCE
  • Page Numbers: pp.435-444
  • Keywords: Combination therapy, hypoxia-ischemia, melatonin, neuroprotection, topiramate, BRAIN-DAMAGE, PROTECTIVE ROLE, CELL-DEATH, NEWBORN, INJURY, REDUCTION, INFANT

Abstract

Purpose: The objective of this study was to compare the effects of two neuroprotective agents; melatonin, a free radical scavenger and topiramate, AMPA/kainate receptor antagonist, administered alone or in combination in neonatal hypoxic-ischemic model.