Neuroprotective effects of melatonin administered alone or in combination with topiramate in neonatal hypoxic-ischemic rat model
RESTORATIVE NEUROLOGY AND NEUROSCIENCE, vol.30, no.5, pp.435-444, 2012 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 30 Issue: 5
- Publication Date: 2012
- Doi Number: 10.3233/rnn-2012-120217
- Journal Name: RESTORATIVE NEUROLOGY AND NEUROSCIENCE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.435-444
- Keywords: Combination therapy, hypoxia-ischemia, melatonin, neuroprotection, topiramate, BRAIN-DAMAGE, PROTECTIVE ROLE, CELL-DEATH, NEWBORN, INJURY, REDUCTION, INFANT
- Bursa Uludag University Affiliated: Yes
Abstract
Purpose: The objective of this study was to compare the effects of two neuroprotective agents; melatonin, a free radical scavenger and topiramate, AMPA/kainate receptor antagonist, administered alone or in combination in neonatal hypoxic-ischemic model.