Neuroprotective effects of melatonin administered alone or in combination with topiramate in neonatal hypoxic-ischemic rat model

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ÖZYENER F., Cetinkaya M., ALKAN T., GÖREN B., KAFA İ. M., Kurt M. A., ...More

RESTORATIVE NEUROLOGY AND NEUROSCIENCE, vol.30, no.5, pp.435-444, 2012 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 30 Issue: 5
• Publication Date: 2012
• Doi Number: 10.3233/rnn-2012-120217
• Journal Name: RESTORATIVE NEUROLOGY AND NEUROSCIENCE
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.435-444
• Keywords: Combination therapy, hypoxia-ischemia, melatonin, neuroprotection, topiramate, BRAIN-DAMAGE, PROTECTIVE ROLE, CELL-DEATH, NEWBORN, INJURY, REDUCTION, INFANT
• Bursa Uludag University Affiliated: Yes

Abstract

Purpose: The objective of this study was to compare the effects of two neuroprotective agents; melatonin, a free radical scavenger and topiramate, AMPA/kainate receptor antagonist, administered alone or in combination in neonatal hypoxic-ischemic model.