CYTOKERATIN 7/20 EXPRESSION PATTERNS AND ASSOCIATION WITH PROGNOSTIC VARIABLES IN GASTRIC ADENOCARCINOMAS


UĞRAŞ N. , ÖZ ATALAY F. , OCAKOĞLU G. , YERCİ Ö.

ACTA MEDICA MEDITERRANEA, vol.30, no.5, pp.1041-1044, 2014 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 5
  • Publication Date: 2014
  • Title of Journal : ACTA MEDICA MEDITERRANEA
  • Page Numbers: pp.1041-1044

Abstract

Aim: The histologic features, potential behavior; genetic pathways, epidemiological characteristics and response to treatment of gastric carcinomas, is showing heterogeneity. Cytokeratin (CK), an intermediate sized filament detected primarily in epithelial Cells. Most commonly used CKs in immunohistochemical studies are CK7, CK20 and these molecules are used as a markers to help identify the site of origin of metastatic carcinomas. The aim of this study to evaluate the expression pattern of CK7 and CK20 molecules in primary adenocarcinoma of the stomach and their relation between clinicopathologic prognostic factors.