CYTOKERATIN 7/20 EXPRESSION PATTERNS AND ASSOCIATION WITH PROGNOSTIC VARIABLES IN GASTRIC ADENOCARCINOMAS

UĞRAŞ N., ÖZ ATALAY F., OCAKOĞLU G., YERCİ Ö.

ACTA MEDICA MEDITERRANEA, vol.30, no.5, pp.1041-1044, 2014 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 5
  • Publication Date: 2014
  • Journal Name: ACTA MEDICA MEDITERRANEA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1041-1044
  • Bursa Uludag University Affiliated: Yes

Abstract

Aim: The histologic features, potential behavior; genetic pathways, epidemiological characteristics and response to treatment of gastric carcinomas, is showing heterogeneity. Cytokeratin (CK), an intermediate sized filament detected primarily in epithelial Cells. Most commonly used CKs in immunohistochemical studies are CK7, CK20 and these molecules are used as a markers to help identify the site of origin of metastatic carcinomas. The aim of this study to evaluate the expression pattern of CK7 and CK20 molecules in primary adenocarcinoma of the stomach and their relation between clinicopathologic prognostic factors.