CYTOKERATIN 7/20 EXPRESSION PATTERNS AND ASSOCIATION WITH PROGNOSTIC VARIABLES IN GASTRIC ADENOCARCINOMAS

UĞRAŞ N., ÖZ ATALAY F., OCAKOĞLU G., YERCİ Ö.

ACTA MEDICA MEDITERRANEA, cilt.30, sa.5, ss.1041-1044, 2014 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 5
  • Basım Tarihi: 2014
  • Dergi Adı: ACTA MEDICA MEDITERRANEA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1041-1044
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Aim: The histologic features, potential behavior; genetic pathways, epidemiological characteristics and response to treatment of gastric carcinomas, is showing heterogeneity. Cytokeratin (CK), an intermediate sized filament detected primarily in epithelial Cells. Most commonly used CKs in immunohistochemical studies are CK7, CK20 and these molecules are used as a markers to help identify the site of origin of metastatic carcinomas. The aim of this study to evaluate the expression pattern of CK7 and CK20 molecules in primary adenocarcinoma of the stomach and their relation between clinicopathologic prognostic factors.